The Binding of Isaac | Daily Run 1st Feb 2026 (First Place ????) - Video

Goal: Jacob & Esau vs. Mega Satan [Normal Difficulty]
Spiciest Stuff: Serpent's Kiss, Lost Fly, Sad Onion, The Wafer, Sol, Cancer (trinket), Revelation, Pyromaniac, Mercurius, Godhead, Scorpio

The month begin as the last month ended... back-to-back J&E?! ????

But wait, like yesterday, this one was actually decent again! Back-to-back good J&E runs is crazy talk!
The angels blessed this one – Revelation and Godhead were dream drops that made these two far more bearable. Enjoyable, in fact.

A lucky appearance of Sol lead us to the Boss Rooms to sneak us into Boss Rush. Still only got in by one second!
Rev lasers through bosses on spawn is the play. A little bit of bonus damage from Best Friend too (sometimes).

Got Sol to thank for Hush too, easy navigation of the Womb floors.
Godhead was in the mix by this point for a convincing win. Took some damage but what do you expect from the hitbox bros.

Homing poison lasers made for an easy Mega Satan fight too. Not one for the books but more than winnable.

Mid-high HP for both fellas throughout.
Lost fly provides an excellent distraction too. Pyromaniac is cool but kinda nerfed only having it for one character.

So a good run again for these guys.
Oh and it's Groundhog Day tomorrow so we're gonna have a THIRD J&E run(!!) – who angered RNGesus?

Best of luck!

Fun rating: ⭐⭐⭐⭐

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